Koch, 41, was scheduled to climb into a Russian Soyuz capsule docked at the station with two other returning crew members and depart at 9:30 p.m. EST on Wednesday after logging 328 days on the orbiting laboratory.
She also achieved a gender milestone in a relatively routine spacewalk with fellow NASA astronaut Jessica Meir last October that marked the first time two women stepped out of the space station at the same time. NASA said Koch's lengthy mission will provide researchers with much-needed data on how the weightlessness of gravity and space radiation affects the female body on long-duration spaceflights.